NSC 344483

NSC 344483 - Names and Identifiers

Name	N-succinimidyl 4-(maleimidome.)cyclo-hexanecarboxylate
Synonyms	SMCC NSC 344483 N-succinimidyl 4-(maleimidome.)cyclo-hexanecarboxylate Trans-4-(Maleimidomethyl)Cyclohexanecarboxylic acid-NHS N-SucciniMidyl 4-(N-MaleiMidoMethyl)cyclohexanecarboxylate N-Succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate N-Succinimidyl4-(N-maleimidomethyl)cyclohexane-1-carboxylate N-Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate trans-4-(Maleimidomethyl)-cyclohexane carboxylic acid-NHS ester N-Succinimidyl 4-(maleimidomethyl)cyclohexanecarboxylate, SMCC 4-(N-Maleimidomethyl)cyclohexanecarboxylic Acid N-Succinimidyl EsterSMCC 4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester SMCC [4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester] 1-[(4-{[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}cyclohexyl)methyl]-1H-pyrrole-2,5-dione Cyclohexanecarboxylic acid, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-, 2,5-dioxo-1-pyrrolidinyl ester
CAS	64987-85-5
EINECS	1592732-453-0
InChI	InChI=1/C16H18N2O6/c19-12-5-6-13(20)17(12)9-10-1-3-11(4-2-10)16(23)24-18-14(21)7-8-15(18)22/h5-6,10-11H,1-4,7-9H2

NSC 344483 - Physico-chemical Properties

Molecular Formula	C16H18N2O6
Molar Mass	334.32
Density	1.42±0.1 g/cm3(Predicted)
Melting Point	180-182 °C (lit.)
Boling Point	501.7±42.0 °C(Predicted)
Flash Point	257.2°C
Solubility	chloroform: 50mg/mL
Vapor Presure	3.38E-10mmHg at 25°C
Appearance	White crystalline powder
Color	White to Off-White
BRN	1555271
pKa	-2.24±0.20(Predicted)
Storage Condition	-20°C
Sensitive	Moisture & Light Sensitive
Refractive Index	1.598
In vitro study	SMCC or sulfo-SMCC can use to conjugate keyhole limpet hemocyanin (KLH) and ovalbumin (OVA). In the the conjugation system, 300 μl KLH or OVA (3 mg) and 30 μl SMCC or Sulfo-SMCC (the final concentration of 0.1 mM) are added in PBS with final volume of 3 ml.
In vivo study	Using the SMCC-conjugation method is able to induce potent immune responses to whole protein or peptide antigens by injection of antigen-coupled syngeneic splenic mononuclear cells in mice.

NSC 344483 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S60 - This material and its container must be disposed of as hazardous waste. S37 - Wear suitable gloves.
WGK Germany	3
FLUKA BRAND F CODES	10-21
HS Code	29280000

NSC 344483 - Introduction

Monoclonal SMCC antibody derivatization binds to low (poly) nucleotides for use in two-step radioimmunotherapy; dihetero-functional cross-linking reagents that incorporate amines as well as sulfhydryl reactivities into extended spacers, typically, in pH 7.5 buffer (6.5-8.5), coupled to molecules containing primary amines by amide bonds, in pH 6.8 buffer (6.5-7.0), via thioether connection, secondary coupling to special molecules containing free sulfhydryl groups; immune crosslinks used to prepare enzymes and hapten carrier molecular combinations, containing 9 atomic connections; an extended fatty spacer, compared with aromatic spacers, makes maleimide stably and preferentially coupled

Last Update：2022-10-16 17:27:42

NSC 344483 - Reference Information

biological activity

SMCC is a protein crosslinker. SMCC conjugates antigen-coupled spleen cells to induce an antigen-specific immune response.

Use

. It conjugates anti-digoxin F (AB '2 fragments to β-galactosidase. Conjugate hIgG to alkaline phosphatase.
monoclonal SMCC antibody derivatization in combination with low (Poly) nucleotides for use in two-step radioimmunotherapy; Bifunctional crosslinking reagents, the amine and thiol reactivity are combined into an expanded spacer, typically in pH 7.5 buffer (6.5-8.5), coupled via an amide bond to a primary amine-containing molecule, secondary coupling to a particular molecule containing free sulfhydryl groups by thioether linkage in pH 6.5 buffer (7.0-); Immunocrosslinks for the preparation of enzymes and combinations of hapten carrier molecules, A spacer containing 9 Atom connections; An extended fatty substance, in comparison with an aromatic spacer, stable preferential coupling of maleimide

Last Update：2024-04-09 21:04:16